Posts Tagged ‘Drugs’
Many older people struggling with high blood pressure is inappropriate and unnecessary drugs prescribed a combination of pressure, a team of Canadian researchers says.
And, they warn, the dual-frequency protocol unjustified can have serious consequences: an increased risk for kidney failure and even death.
The two types of drugs in question are the angiotensin converting enzyme (ACE) inhibitors and blockers, angiotensin receptor (ARBs).
On their own, each is well established and highly effective in controlling blood pressure, the study team said. In addition, a small number of people – those diagnosed with a blood pressure problem in particular related to inappropriate left ventricular systolic function – you can get any additional benefit of taking the two drugs at the same time, they say.
But older people do not need both drugs, the researchers say, especially considering fresh indication that there is usually much more to lose than win.
No wonder the use of this combination of agents is often not based guide, as is often assumed that if only two drugs are beneficial, then the combination of the two must be even more beneficial, he said the study’s lead author, Dr. Finlay A. McAlister, division of general internal medicine and Mazankowski Alberta Heart Institute at the University of Alberta in Edmonton, Canada.
But McAlister said that research has indicated that this is not the case of the mixture of ACE inhibitors and ARBs, and the new study confirms the risks of this combination. The findings were reported March 21 in the Canadian Medical Journal.
The research involved 32,312 people, all aged 65, who were taking an ACE inhibitor alone, an ARB alone or a combination of both.
The team noted that among the approximately 5% taking both drugs, the vast majority – over 86% – do not have a condition that justifies a combination regimen.
They also found that people with combination therapy is not best fit the scheme, most had stopped taking the medication within three months, even in the absence of serious illness or side effects. The researchers speculated that the arterial hypotension was the main reason for abandoning the routine.
Those who stay with the dual-drug protocol were found to be more likely to experience end-stage renal disease or kidney failure or death than were those who took either drug alone.
Dr. Bryan Henry, an assistant professor of medicine at Finger Lakes Cardiology Associates of the University Of Rochester Medical Center in New York, expressed surprise with the results.
There has been growing evidence for years that the combination or not add anything or may be harmful, “said Henry. For some small subset of patients, could help. But in general, these drugs should not be used in combination.
But readers, Henry was quick to add, do not bring home the message that each drug alone is not safe and effective. It’s just the combination that is a problem.
Dr. Gregg C. Fonarow, a professor of cardiology at the University of California, Los Angeles, expressed hope that the medical community’s attention to the obvious risks involved with the combination of the two drugs.
A number of clinical studies have shown no added benefit of taking two drugs together, and the combination is not recommended in treatment guidelines, he said. So it’s really surprising that many patients were receiving anyway.
But now this is an opportunity for physicians to become aware of the risks outweighing the benefits for patients, Fonarow said. It is certainly a risk that must be avoided.
Drugs, one of the main substances that cause this is tetracycline, which is usually provided to people with severe acne pictures. This antibiotic is known to cause severe tooth discoloration.
Also, foods like soy sauce, grapes, curry, coffee, tea, red wine and, of course, cigarettes also cause stains and yellow teeth. Especially foods that are slightly acidic, which allow stains left by food from sticking to teeth.
Methods for whitening teeth: their pros and contra dientes blancos2
One issue that must be considered, regardless of method used to whiten your teeth, that can only be achieved, usually a white relative. It happens that the most likely do not have, from night to morning, bright white teeth, but also would not look so good, it would not be natural. The basic rule in the bleaching of teeth, is that they are not whiter than the whites of their eyes.
1. Toothpastes
The dental bleaching toothpastes work gradually, and usually takes several weeks to show results. The drawback is that they are abrasive, so that over time can weaken truly the tooth enamel and make it look the same, just more yellow. So, you should check the ingredients to see how abrasive is on them. The Calprox is an ingredient that can replace certain mild abrasive and should not cause damage to teeth.
2. Tools
To remove stains, there are tools that are used almost like an eraser to teeth. These tools will remove the stains without damaging the teeth, usually work best when used with a teeth whitening toothpaste, and are especially good to use after eating or drinking anything that can stain.
3. Movies whitening
There is also a method that consists of a film of bleaching agents that is placed on the teeth. It sticks and is virtually invisible. While it works well, it can take weeks to achieve results, and again, the gums should be well protected.